Does sleep affect your immune system?

Strongly. Even one night of short sleep reduces immune cell activity by 30%+. Chronic insufficient sleep increases susceptibility to infections and impairs vaccine response.

The cold-risk study

Prather et al. (2015) infected 164 volunteers with rhinovirus and tracked sleep. Those who slept under 6 hours per night were 4.2× more likely to develop a cold than those sleeping 7+ hours.

Vaccine response

Studies on flu and hepatitis vaccines show 50%+ weaker antibody response in sleep-deprived adults. The vaccine works, but less effectively.

The mechanism

Natural killer cell activity drops sharply after even a single short night. Inflammatory cytokines rise. Both contribute to lower infection resistance.

Sources

  1. Prather et al., Sleep, 2015. Behaviorally Assessed Sleep and Susceptibility to the Common Cold

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